mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway.
Identifieur interne : 000170 ( Main/Exploration ); précédent : 000169; suivant : 000171mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway.
Auteurs : Zhou Lyu [République populaire de Chine] ; Xuejie Gao [République populaire de Chine] ; Weiyan Wang [République populaire de Chine] ; Jinye Dang [République populaire de Chine] ; Li Yang [République populaire de Chine] ; Mengli Yan [République populaire de Chine] ; Shah Arman Ali [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Binghua Liu [République populaire de Chine] ; Meng Yu [République populaire de Chine] ; Linfang Du [République populaire de Chine] ; Ke Liu [République populaire de Chine]Source :
- Aging [ 1945-4589 ] ; 2019.
Descripteurs français
- KwdFr :
- Complexe-1 cible mécanistique de la rapamycine (métabolisme), Cystathionine beta-synthase (métabolisme), Cystathionine gamma-lyase (métabolisme), Diétothérapie (MeSH), Humains (MeSH), Lignée cellulaire (MeSH), Protein-Serine-Threonine Kinases (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines fongiques (métabolisme), Saccharomyces cerevisiae (MeSH), Sulfure d'hydrogène (métabolisme), Transduction du signal (MeSH).
- MESH :
- métabolisme : Complexe-1 cible mécanistique de la rapamycine, Cystathionine beta-synthase, Cystathionine gamma-lyase, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Protéines fongiques, Sulfure d'hydrogène.
- Diétothérapie, Humains, Lignée cellulaire, Saccharomyces cerevisiae, Transduction du signal.
English descriptors
- KwdEn :
- Cell Line (MeSH), Cystathionine beta-Synthase (metabolism), Cystathionine gamma-Lyase (metabolism), Diet Therapy (MeSH), Fungal Proteins (metabolism), Humans (MeSH), Hydrogen Sulfide (metabolism), Mechanistic Target of Rapamycin Complex 1 (metabolism), Protein-Serine-Threonine Kinases (metabolism), Saccharomyces cerevisiae (MeSH), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (MeSH).
- MESH :
- chemical , metabolism : Cystathionine beta-Synthase, Cystathionine gamma-Lyase, Fungal Proteins, Hydrogen Sulfide, Mechanistic Target of Rapamycin Complex 1, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins.
- Cell Line, Diet Therapy, Humans, Saccharomyces cerevisiae, Signal Transduction.
Abstract
Endogenous hydrogen sulfide mediates anti-aging benefits of dietary restriction (DR). However, it is unclear how H2S production is regulated by pathways related to DR. Due to the importance of mTORC1 pathway in DR, we investigated the effects of Sch9, a yeast homolog of mammalian S6K1 and a major substrate of mTORC1 on H2S production in yeast Saccharomyces cerevisiae. We found that inhibition of the mTORC1-Sch9 pathway by SCH9 deletion, rapamycin or myriocin treatment resulted in a dramatic decrease in H2S production. Although deficiency of SCH9 did not alter the intracellular level of methionine, the intracellular level of cysteine increased in Δsch9 cells. The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Overexpression of CYS3 or CYS4 in Δsch9 cells or WT cells treated with rapamycin rescued the deficiency of H2S production. Finally, we also observed a reduction in H2S production and lowering of both mRNA and protein levels of CGL and CBS in cultured human cells treated with rapamycin to reduce mTORC1 pathway activity. Thus, our findings reveal a probably conserved mechanism in which H2S production by the transsulfuration pathway is regulated by mTORC1-Sch9 signaling.
DOI: 10.18632/aging.102327
PubMed: 31582588
PubMed Central: PMC6814617
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway.</title><author><name sortKey="Lyu, Zhou" sort="Lyu, Zhou" uniqKey="Lyu Z" first="Zhou" last="Lyu">Zhou Lyu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xuejie" sort="Gao, Xuejie" uniqKey="Gao X" first="Xuejie" last="Gao">Xuejie Gao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Weiyan" sort="Wang, Weiyan" uniqKey="Wang W" first="Weiyan" last="Wang">Weiyan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Dang, Jinye" sort="Dang, Jinye" uniqKey="Dang J" first="Jinye" last="Dang">Jinye Dang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Mengli" sort="Yan, Mengli" uniqKey="Yan M" first="Mengli" last="Yan">Mengli Yan</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Shah Arman" sort="Ali, Shah Arman" uniqKey="Ali S" first="Shah Arman" last="Ali">Shah Arman Ali</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Binghua" sort="Liu, Binghua" uniqKey="Liu B" first="Binghua" last="Liu">Binghua Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Biology, College of Medicine, Chengdu University, Chengdu 610106, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Biology, College of Medicine, Chengdu University, Chengdu 610106, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Du, Linfang" sort="Du, Linfang" uniqKey="Du L" first="Linfang" last="Du">Linfang Du</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31582588</idno><idno type="pmid">31582588</idno><idno type="doi">10.18632/aging.102327</idno><idno type="pmc">PMC6814617</idno><idno type="wicri:Area/Main/Corpus">000183</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000183</idno><idno type="wicri:Area/Main/Curation">000183</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000183</idno><idno type="wicri:Area/Main/Exploration">000183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway.</title><author><name sortKey="Lyu, Zhou" sort="Lyu, Zhou" uniqKey="Lyu Z" first="Zhou" last="Lyu">Zhou Lyu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xuejie" sort="Gao, Xuejie" uniqKey="Gao X" first="Xuejie" last="Gao">Xuejie Gao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Weiyan" sort="Wang, Weiyan" uniqKey="Wang W" first="Weiyan" last="Wang">Weiyan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Dang, Jinye" sort="Dang, Jinye" uniqKey="Dang J" first="Jinye" last="Dang">Jinye Dang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Mengli" sort="Yan, Mengli" uniqKey="Yan M" first="Mengli" last="Yan">Mengli Yan</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Shah Arman" sort="Ali, Shah Arman" uniqKey="Ali S" first="Shah Arman" last="Ali">Shah Arman Ali</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Binghua" sort="Liu, Binghua" uniqKey="Liu B" first="Binghua" last="Liu">Binghua Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Molecular Biology, College of Medicine, Chengdu University, Chengdu 610106, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Biology, College of Medicine, Chengdu University, Chengdu 610106, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Du, Linfang" sort="Du, Linfang" uniqKey="Du L" first="Linfang" last="Du">Linfang Du</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Aging</title><idno type="eISSN">1945-4589</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line (MeSH)</term><term>Cystathionine beta-Synthase (metabolism)</term><term>Cystathionine gamma-Lyase (metabolism)</term><term>Diet Therapy (MeSH)</term><term>Fungal Proteins (metabolism)</term><term>Humans (MeSH)</term><term>Hydrogen Sulfide (metabolism)</term><term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term><term>Protein-Serine-Threonine Kinases (metabolism)</term><term>Saccharomyces cerevisiae (MeSH)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Signal Transduction (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term><term>Cystathionine beta-synthase (métabolisme)</term><term>Cystathionine gamma-lyase (métabolisme)</term><term>Diétothérapie (MeSH)</term><term>Humains (MeSH)</term><term>Lignée cellulaire (MeSH)</term><term>Protein-Serine-Threonine Kinases (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Protéines fongiques (métabolisme)</term><term>Saccharomyces cerevisiae (MeSH)</term><term>Sulfure d'hydrogène (métabolisme)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cystathionine beta-Synthase</term><term>Cystathionine gamma-Lyase</term><term>Fungal Proteins</term><term>Hydrogen Sulfide</term><term>Mechanistic Target of Rapamycin Complex 1</term><term>Protein-Serine-Threonine Kinases</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Cystathionine beta-synthase</term><term>Cystathionine gamma-lyase</term><term>Protein-Serine-Threonine Kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines fongiques</term><term>Sulfure d'hydrogène</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Diet Therapy</term><term>Humans</term><term>Saccharomyces cerevisiae</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Diétothérapie</term><term>Humains</term><term>Lignée cellulaire</term><term>Saccharomyces cerevisiae</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Endogenous hydrogen sulfide mediates anti-aging benefits of dietary restriction (DR). However, it is unclear how H<sub>2</sub>S production is regulated by pathways related to DR. Due to the importance of mTORC1 pathway in DR, we investigated the effects of Sch9, a yeast homolog of mammalian S6K1 and a major substrate of mTORC1 on H<sub>2</sub>S production in yeast <i>Saccharomyces cerevisiae</i>. We found that inhibition of the mTORC1-Sch9 pathway by <i>SCH9</i> deletion, rapamycin or myriocin treatment resulted in a dramatic decrease in H<sub>2</sub>S production. Although deficiency of <i>SCH9</i> did not alter the intracellular level of methionine, the intracellular level of cysteine increased in <i>Δsch9</i> cells. The expression of <i>CYS3</i> and <i>CYS4</i>, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Overexpression of <i>CYS3</i> or <i>CYS4</i> in <i>Δsch9</i> cells or WT cells treated with rapamycin rescued the deficiency of H<sub>2</sub>S production. Finally, we also observed a reduction in H<sub>2</sub>S production and lowering of both mRNA and protein levels of CGL and CBS in cultured human cells treated with rapamycin to reduce mTORC1 pathway activity. Thus, our findings reveal a probably conserved mechanism in which H<sub>2</sub>S production by the transsulfuration pathway is regulated by mTORC1-Sch9 signaling.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31582588</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1945-4589</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>19</Issue><PubDate><Year>2019</Year><Month>10</Month><Day>03</Day></PubDate></JournalIssue><Title>Aging</Title><ISOAbbreviation>Aging (Albany NY)</ISOAbbreviation></Journal><ArticleTitle>mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway.</ArticleTitle><Pagination><MedlinePgn>8418-8432</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.18632/aging.102327</ELocationID><Abstract><AbstractText>Endogenous hydrogen sulfide mediates anti-aging benefits of dietary restriction (DR). However, it is unclear how H<sub>2</sub>S production is regulated by pathways related to DR. Due to the importance of mTORC1 pathway in DR, we investigated the effects of Sch9, a yeast homolog of mammalian S6K1 and a major substrate of mTORC1 on H<sub>2</sub>S production in yeast <i>Saccharomyces cerevisiae</i>. We found that inhibition of the mTORC1-Sch9 pathway by <i>SCH9</i> deletion, rapamycin or myriocin treatment resulted in a dramatic decrease in H<sub>2</sub>S production. Although deficiency of <i>SCH9</i> did not alter the intracellular level of methionine, the intracellular level of cysteine increased in <i>Δsch9</i> cells. The expression of <i>CYS3</i> and <i>CYS4</i>, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition. Overexpression of <i>CYS3</i> or <i>CYS4</i> in <i>Δsch9</i> cells or WT cells treated with rapamycin rescued the deficiency of H<sub>2</sub>S production. Finally, we also observed a reduction in H<sub>2</sub>S production and lowering of both mRNA and protein levels of CGL and CBS in cultured human cells treated with rapamycin to reduce mTORC1 pathway activity. Thus, our findings reveal a probably conserved mechanism in which H<sub>2</sub>S production by the transsulfuration pathway is regulated by mTORC1-Sch9 signaling.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lyu</LastName><ForeName>Zhou</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Xuejie</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Weiyan</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dang</LastName><ForeName>Jinye</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Mengli</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ali</LastName><ForeName>Shah Arman</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Binghua</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Molecular Biology, College of Medicine, Chengdu University, Chengdu 610106, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Linfang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, Sichuan, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Aging (Albany NY)</MedlineTA><NlmUniqueID>101508617</NlmUniqueID><ISSNLinking>1945-4589</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C530964">SCH9 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.2.1.22</RegistryNumber><NameOfSubstance UI="D003541">Cystathionine beta-Synthase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.4.1.1</RegistryNumber><NameOfSubstance UI="C073674">CYS3 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.4.1.1</RegistryNumber><NameOfSubstance UI="D003542">Cystathionine gamma-Lyase</NameOfSubstance></Chemical><Chemical><RegistryNumber>YY9FVM7NSN</RegistryNumber><NameOfSubstance UI="D006862">Hydrogen Sulfide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003541" MajorTopicYN="N">Cystathionine beta-Synthase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003542" MajorTopicYN="N">Cystathionine gamma-Lyase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004035" MajorTopicYN="N">Diet Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006862" MajorTopicYN="N">Hydrogen Sulfide</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="Y">Saccharomyces cerevisiae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Sch9</Keyword><Keyword MajorTopicYN="Y">cystathionine beta-synthase</Keyword><Keyword MajorTopicYN="Y">cystathionine gamma-lyase</Keyword><Keyword MajorTopicYN="Y">hydrogen sulfide</Keyword><Keyword MajorTopicYN="Y">mTORC1</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31582588</ArticleId><ArticleId IdType="doi">10.18632/aging.102327</ArticleId><ArticleId IdType="pii">102327</ArticleId><ArticleId IdType="pmc">PMC6814617</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Essays Biochem. 2017 Dec 12;61(6):565-584</Citation><ArticleIdList><ArticleId IdType="pubmed">29233869</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Metab. 2017 Aug 1;26(2):301-309</Citation><ArticleIdList><ArticleId IdType="pubmed">28768171</ArticleId></ArticleIdList></Reference><Reference><Citation>Oxid Med Cell Longev. 2016;2016:9049782</Citation><ArticleIdList><ArticleId IdType="pubmed">27413423</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2017 Jun 12;13(6):e1006835</Citation><ArticleIdList><ArticleId IdType="pubmed">28604780</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2017 Oct 1;27(10):634-653</Citation><ArticleIdList><ArticleId IdType="pubmed">28398086</ArticleId></ArticleIdList></Reference><Reference><Citation>Appl Environ Microbiol. 2008 Mar;74(5):1418-27</Citation><ArticleIdList><ArticleId IdType="pubmed">18192430</ArticleId></ArticleIdList></Reference><Reference><Citation>Nutr Res Rev. 2015 Dec;28(2):100-120</Citation><ArticleIdList><ArticleId IdType="pubmed">26391585</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Signal. 2015 Apr 28;8(374):rs4</Citation><ArticleIdList><ArticleId IdType="pubmed">25921291</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2017 Jul 27;547(7664):476</Citation><ArticleIdList><ArticleId IdType="pubmed">28700577</ArticleId></ArticleIdList></Reference><Reference><Citation>Yeast. 1991 Nov;7(8):843-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1789005</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2009 May;5(5):e1000467</Citation><ArticleIdList><ArticleId IdType="pubmed">19424415</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 1967 Aug;104(2):627-33</Citation><ArticleIdList><ArticleId IdType="pubmed">6048802</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2012 Feb;8(2):e1002493</Citation><ArticleIdList><ArticleId IdType="pubmed">22319457</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2003 Aug;5(4):493-501</Citation><ArticleIdList><ArticleId IdType="pubmed">13678538</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2007 Jun 8;26(5):663-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17560372</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann N Y Acad Sci. 2016 Jan;1363:155-70</Citation><ArticleIdList><ArticleId IdType="pubmed">26995762</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2001 Apr 13;292(5515):288-90</Citation><ArticleIdList><ArticleId IdType="pubmed">11292860</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2009 Aug 14;284(33):22457-66</Citation><ArticleIdList><ArticleId IdType="pubmed">19531479</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2016 Jul 14;166(2):436-450</Citation><ArticleIdList><ArticleId IdType="pubmed">27345368</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2000 Aug 4;102(3):303-14</Citation><ArticleIdList><ArticleId IdType="pubmed">10975521</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2011 Oct 24;50(44):10327-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21898737</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Genet. 2008 Jan;4(1):e13</Citation><ArticleIdList><ArticleId IdType="pubmed">18225956</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Enzymol. 2015;554:3-29</Citation><ArticleIdList><ArticleId IdType="pubmed">25725513</ArticleId></ArticleIdList></Reference><Reference><Citation>Redox Biol. 2015 Aug;5:290-300</Citation><ArticleIdList><ArticleId IdType="pubmed">26087116</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microbiol Methods. 2012 Oct;91(1):165-70</Citation><ArticleIdList><ArticleId IdType="pubmed">22981795</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2015 Jan 15;160(1-2):132-44</Citation><ArticleIdList><ArticleId IdType="pubmed">25542313</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Genet. 2008 Apr;53(4):225-34</Citation><ArticleIdList><ArticleId IdType="pubmed">18317767</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Pharmacol. 2017 Sep 26;8:686</Citation><ArticleIdList><ArticleId IdType="pubmed">29018349</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Cell Biol. 2014 Jul;24(7):400-6</Citation><ArticleIdList><ArticleId IdType="pubmed">24698685</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2017 Feb 17;429(4):543-561</Citation><ArticleIdList><ArticleId IdType="pubmed">28013031</ArticleId></ArticleIdList></Reference><Reference><Citation>Yeast. 2000 Jun 30;16(9):857-60</Citation><ArticleIdList><ArticleId IdType="pubmed">10861908</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Lyu, Zhou" sort="Lyu, Zhou" uniqKey="Lyu Z" first="Zhou" last="Lyu">Zhou Lyu</name></noRegion><name sortKey="Ali, Shah Arman" sort="Ali, Shah Arman" uniqKey="Ali S" first="Shah Arman" last="Ali">Shah Arman Ali</name><name sortKey="Dang, Jinye" sort="Dang, Jinye" uniqKey="Dang J" first="Jinye" last="Dang">Jinye Dang</name><name sortKey="Du, Linfang" sort="Du, Linfang" uniqKey="Du L" first="Linfang" last="Du">Linfang Du</name><name sortKey="Gao, Xuejie" sort="Gao, Xuejie" uniqKey="Gao X" first="Xuejie" last="Gao">Xuejie Gao</name><name sortKey="Liu, Binghua" sort="Liu, Binghua" uniqKey="Liu B" first="Binghua" last="Liu">Binghua Liu</name><name sortKey="Liu, Binghua" sort="Liu, Binghua" uniqKey="Liu B" first="Binghua" last="Liu">Binghua Liu</name><name sortKey="Liu, Ke" sort="Liu, Ke" uniqKey="Liu K" first="Ke" last="Liu">Ke Liu</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Wang, Weiyan" sort="Wang, Weiyan" uniqKey="Wang W" first="Weiyan" last="Wang">Weiyan Wang</name><name sortKey="Yan, Mengli" sort="Yan, Mengli" uniqKey="Yan M" first="Mengli" last="Yan">Mengli Yan</name><name sortKey="Yang, Li" sort="Yang, Li" uniqKey="Yang L" first="Li" last="Yang">Li Yang</name><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000170 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000170 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31582588
|texte= mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31582588" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |